Indigenous People, Genes and Genetics
What Indigenous People Should Know About Biocolonialism
A Primer and Resource Guide
Essentials of Genetics
Then and Now ó Genetic Engineering ó The Basics
of Human Genetics ó How a Transgenic Plant is Made
ó The Current Status of Human Genetic Research ó The Current
Status of Agricultural Genetics
Some Implications of
Genetic Research for Indigenous Peoples ó
Genetic Research Ethics
Fail to Address Concerns of Indigenous Peoples ó Conflict
with Common Indigenous Principles and Ethics ó Supplanting World
Views ó Group View of Inheritance ó Commercialization
and Ownership of Life ó Gene Banking and Immortalized
DNA ó Sanctity of Our Ancestors ó Euro-centric
Scientific Theory and Discrimination ó Genetic Discrimination
ó Eugenics and Genocidal Practices ó Funding Priorities
Some Problems with Genetics
in Agriculture ó
Colonizing and Owning Life ó Introducing New Species
ó Farmers and Farming Communities ó Health ó Technical
Solutions Cannot Fix Policy Problems
What Can Indigenous People Do?
ó Recommended Reading ó Organizations
Back to IPCB Publications Page v Back to IPCB Home Page
In Memory of
Dr. Frank Dukepoo
This publication is dedicated to Dr. Frank Dukepoo,
a geneticist of Hopi and Laguna ancestry, who set his own research aside in order to insure that indigenous peoples'
human rights and interests would be protected in the face of the new biotechnologies. Dr. Dukepoo was a founding
member of the board of directors of the IPCB, and a treasured mentor and friend. He was the co-author of the original
version of Indians, Genes and Genetics:
What Indians Should Know About the New Biotechnology, the publication on which this booklet is based. Dr. Dukepoo's
dedication and commitment to insure that the treatment of indigenous peoples in research is ethical, responsible,
and respectful has been a continuing source of inspiration and a guiding light to our ongoing efforts.
"To us, any part of
ourselves is sacred. Scientists say it's just DNA. For an Indian, it is not just DNA, it's part of a person, it
is sacred, with deep religious significance. It is part of the essence of a person."
Dr. Frank Dukepoo, Interview,
San Francisco Chronicle, 1998
peoples of the world are unique groups who are widely known by our diverse cultures, customs, and languages. Despite
our differences, however, we share many similarities. Our early ancestors made significant contributions to astronomy,
arts, architecture, agriculture, mathematics, ecology, social science, political science, and genetics. The results
of our contributions are evident throughout the world. How far we would have gone in these areas is unknown because
our recent ancestors put them aside as they were forced to contend with colonization.
Call it ìthe new wave of colonialism,î
ìthe new biotechnology,î ìthe bio-revolution,î or bio-colonialism,î it is here and will be with us for a long time.
times our ancestors fought their battles on land and in courtrooms. Today some of the battles have moved to scientific
laboratories and patent offices. Our weapons are awareness, knowledge, and choices, rather than arrows, guns, and
treaties. Call it "the new wave of colonialism," "the new biotechnology," "the bio-revolution,"
or "bio-colonialism," it is here and will be with us for a long time. In a very broad sense, what we
are talking about is "biotechnology." It is an area that we dare not ignore.
we hear the word "biotechnology," many of us turn away our minds, thinking that this field of science
seems too hard to understand or that it is "not Indian." Until recently, very few of us had heard about
the science of genetics. But we cannot afford to ignore this field of science any longer, because the genomics
industry, both public and private, wants and needs the genetic resources that exist within the biodiversity of
indigenous peoples' lands and that flows in our veins. The immense resources of technology-rich countries are being
pooled in worldwide collaborations in order to carry out genetic research. Also, numerous researchers are funded
by both public and private funds to carry out their own independent research activities. These efforts, combined
with increased technological capabilities for genetic sequencing, are fueling a worldwide effort to collect genetic
samples, from plants that produce foods or medicines, from animals, and from diverse human populations. The genetic
resources that have nurtured the lives of indigenous societies for centuries are at risk of genetic theft.
field of molecular biology is moving ahead extremely fast. In fact, the field has outpaced the development of new
policies and laws that can effectively address the legal, social, and ethical concerns that genetic research raises
for society. Scientists and bioethicists regularly have conferences to discuss ethical issues such as genetic discrimination
in the workplace or in insurance coverage. Or they may be concerned about the dilemma parents face when genetic
screening of unborn children indicates a predisposition for a disease, but offers no cure for that disease. Others
debate the ethics of altering genes in unborn fetuses, human cloning, and animal organ transplants into humans
despite the risks of transferring viruses between species. They also often meet to discuss the unique questions
raised when they would like to do genetic research on indigenous peoples, but indigenous peoples are rarely at
the table to represent our own views.
indigenous people have taken a more critical look at genetics, many have voiced their concern and have started
to speak out against some of the negative aspects of biotechnology. In fact, a widespread movement against genetic
theft, or biopiracy, has started to build around the world. Many of the protesters at the World Trade Organization
meeting in late 1999 in Seattle were opposed to the negative impacts biotechnology can have when the interests
of corporations are favored over societal needs. Those opposed to the control corporations have over science and
genetic resources include a broad range of people, from indigenous peoples to shareholder activists, from students
to tenured professors.
purpose of this booklet is to provide you with a "primer" to help you build a foundation and have a better
understanding of the complex subject of genetics. This essential knowledge will enable you to better understand
the issues and make more informed decisions regarding yourself, your people, and your environment.
we begin, we want to emphasize that we do not intend to tell you what to do or make decisions for you, be they
pro or con. Our intent is to present the subject and the issues so that you can make intelligent, well thought-out
and informed decisions about genetic research in indigenous communities. We present a broad perspective on the
concerns and potential negative aspects of genetic research. We can't expect or rely upon the researchers, corporations,
media, or government officials to present all of the information we need to know. It is possible they may be more
interested in protecting their own interests rather than ours, or they simply may not know what information is
important to us. To make a good decision, you need to have the opportunity to be fully informed of every aspect
of the research, and to weigh the potential benefits with the risks. The final decisions are, of course, yours
to make. We want to provide you with the whole picture because your decisions are important and they will affect
all of us.
is concerned with studying the genetic composition of life forms at the cellular level, be it viruses, bacteria,
plants, animals, or human. The genetic material, or DNA, is found within the cells and contains the hereditary
information passed on through reproduction from generation to generation. DNA contains certain biological/chemical
instructions that, when combined with environmental influences, result in the biological (physical) development
of the organism. Scientists are concerned with understanding the structure and sequences of genes, identifying
genes associated with various physical conditions, and they sometimes attempt to change the genetic structure of
organisms through genetic manipulations. Genetics, as a discipline, has little regard for the life forms it manipulates.
Their interventions-inserting foreign genetic material into an organism, adding or deleting genes- can permanently
alter life forms that have evolved naturally over thousands of years.
contrasts sharply with an indigenous worldview. For us, all life is sacred-it is a gift from the Creator. As indigenous
peoples, we carry the responsibility of insuring a healthy future for our children and unborn generations yet to
come. This includes a responsibility to respect, protect, and nurture all life. Life is sustained by a healthy
environment. In order to carry out our responsibilities to future generations and our environments, we need to
understand the nature of the problems we face. Once fully aware, then we are prepared to take action in order to
carry out our responsibilities.
issue of biocolonialism has come knocking at our doors. Like all other unwanted advances of colonization within
our lives and territories, genetic prospecting is a reality and is here to stay. Much of life's genetic diversity
exists among our peoples and in our territories. Genetic diversity flourishes where lands have not been clear-cut
to make way for the expansion of cities, farming, or ranching activities, and where small scale crop diversity
is the norm rather than large-scale mono-cropping. Researchers know full well that this is where they will find
the genetic diversity, human, animal and plant, needed for their research projects. As an indigenous person you
should be concerned, since you might have an unusual genetic makeup-you might possess a rare gene or suffer from
an "important" disease or medical condition, thereby making you a prime candidate in some research project.
If you choose to participate in studies involving genetics, that is your choice, but we urge you to consider the
- Am I fully aware of the research I am getting into?
- Do I really understand what is going on?
- Am I aware of the short and long-term effects of such research?
- Have I weighed the positive as well as negative outcomes?
- Does this violate or go against my religion, my culture or my
personal code of ethics?
- Do I really know what is in the "consent form"?
- Have I given my true consent?
- Do I know what will be done with my blood, tissue, hair or other
- What use will be made of our tribal knowledge, or of samples
removed from our territory?
- How will the research results affect me, my family, or my people?
- Who really benefits from the research, and how much?
are extremely important questions. They are questions and issues that all of us must face as we enter the "bio-revolution."
They will help you evaluate research proposals and take control over how this revolution will affect you. Collectively,
as tribal peoples, we can also play a role in determining how this revolution moves forward and how we may choose
to participate, or not.
addition to human research, we also know there is an increased interest in plant or botanical research, as seed
and pharmaceutical companies seek to "discover" and patent the agricultural and medicinal properties
of our native plants, and the knowledge of our elders and medicine people.
the next section we will provide an overview of the science of genetics. Then we will discuss some of the areas
of specific concern to indigenous peoples. Finally, we will provide some ideas about what you can do, and some
resources for you to learn more if you would like to do so.
of Section v
Then and Now
Engineering ó The Basics of Human Genetics ó How a Transgenic Plant is Made ó The Current Status of Human Genetic Research ó The Current Status of Agricultural Genetics
Then and Now
is the study of the structure and function of genes and of the transmission of genes between generations. Knowledge
of genetic phenomena has a history that is thousands of years old and probably began when humans first noticed
similarities between parents and offspring, or that certain traits or characteristics "run" in families.
Ancient civilizations, including the Chinese, Romans, and Egyptians, applied this knowledge to "develop"
many different domesticated animals. Throughout the centuries, indigenous peoples in the Western Hemisphere have
developed many varieties of plants such as corn, potatoes, beans, squash, and other edibles. Present-day indigenous
peoples still maintain different strains of plants, developed over generations of cultivation.
incredibly fast growth of the "new genetics" is another story altogether. It started when it was found
that humans could move portions of DNA (genes) between organisms (human and other life forms), and so the genetic
engineering revolution began. And that "revolution" marches on at breakneck speed. Almost daily there
are new developments in the "discovery" of "new" genes. Molecular biological techniques have
found their way into the courtroom, as documented by the well-publicized trial of O. J. Simpson. In 1997 the world
was stunned by the news of "Dolly," the cloned sheep, and two weeks later news coverage featured cloned
Rhesus monkeys from a University of Oregon lab. In January of 1998, we learned that longevity might be extended
by manipulating certain parts of the chromosome and that a scientist in Chicago (Richard Seed) was proposing to
clone humans. In the year 2000, the UK has proposed to lift its ban on human cloning.
research in the agricultural world, though less susceptible to sensation in the press, is moving equally fast as
scientists are attempting to identify the genes that produce commercially valuable properties by studying plant
and animal genetic material. "Traitor Technologies", that engineer seeds to infertile after planting,
captured the attention of the press and the public. Further concerns were raised when researchers found that genetically
engineered crops were killing the Monarch butterfly.
of Section v
Genetic engineering is an aspect of genetics that
attempts to make changes in the DNA of an organism. Typically, this is done by putting pieces of DNA from another
source into a life form. When this is done to nonreproductive ("somatic") tissues the changes only remain
in effect during the lifetime of the altered individual. However, when this type of manipulation is done during
early embryonic stages, the changes can be incorporated into the developing eggs or sperm ("germ cells"),
and may therefore be passed on to offspring of the manipulated organism. Genetic alteration of somatic tissues
is sometimes called "somatic gene therapy" or "somatic gene engineering", but because of the
inexact nature of the science it is more proper just to call it "somatic gene manipulation". Similarly,
genetic alterations that can be passed on to future generations should be indentified as "germline manipulation".
A more detailed
The science of human genetics can focus on a broad variety of topics. Some geneticists study
traits we inherit from our parents, some study similar traits within a population and differences between populations,
some are looking at genetics from a historical perspective to study the history of populations, their relationships
with others, while others are looking at current health-related questions.
People inherit a mix of genes from each of their parents. Each of your genes is present in two
copies. One copy comes from your mother, and the other copy from your father, but the two copies do not always
have an equal impact on your biology. This can contribute to your being more like your father in some ways and
more like your mother in other ways. The genes you inherit from your parents they inherited from their parents,
and so on. Surprisingly, the version of a gene you get from one of your parents may have been silent in their own
bodies, but simply passed on from one of their own parents. This is why in certain respects you can resemble your
grandparents more than your parents. If you have children, you will pass some of the ancestral genetic information
you received on to them.
Since DNA is in every cell of the body, scientists can obtain a sample of a person's genes from
virtually any tissue sample, like blood, hair, or bones. Once they obtain a sample, they can perform procedures
that cause the genes to be copied over and over. Therefore, just one small sample is enough to create a supply
of a person's genetic samples that is never-ending. The cells become "immortalized."
The Basics of Human Genetics
This section provides an introduction to some of the more technical scientific background about
genetics. It will help explain some of the technical language used by scientists, and will provide some of the
essential details about what genes are and how they work.
After fertilization has occurred, a single cell called a zygote is formed. The zygote contains
all of the genetic material necessary for an individual to grow and develop. This cell divides rapidly and becomes
an embryo, then a fetus, and eventually a baby is born. By adulthood, a human is composed of trillions of cells-all
from one initial cell. Each of these cells, except for red blood cells, contains a full set of human genetic material.
A typical cell has two major areas, called the "cytoplasm" and the "nucleus."
Within the cytoplasm are found organelles, which keep the cell functioning. Also enclosed within the cytoplasm
is the membrane-bound nucleus, which contains the genetic material. At certain times this material is diffuse,
not easily seen, and is known as chromatin. At other times the chromatin condenses into visible chromosomes. Embedded
in the chromosomes are genes which occupy specific sites called loci.
Chromosomes come in pairs as do their accompanying genes. For each species, the total number
of chromosomes is constant. Fruitflies, for example, have 4 pairs of chromosomes. Each human cell contains 46 total
chromosomes (23 from the mother and 23 from the father). The 23 pairs are made up of 22 pairs of autosomes and
1 pair of sex chromosomes. Males have an X and a Y sex chromosome, while females have two X sex chromosomes.The
total genetic material, all the chromosomes together, is known as the "genome."
Chromosomes are visible because they are tightly coiled. However, if we were to unwind a chromosome,
we would discover that it is bound with histone proteins. If we continue to unwind, we find the structure of the
DNA molecule as postulated by James Watson and Francis Crick in 1953: the "double helix."
Chemically, DNA is composed of common elements including carbon, hydrogen, oxygen, nitrogen
and phosphorus and takes on the shape of a twisted ladder. In this "double helix" the outer supports
of the "ladder" are composed of deoxyribose sugar alternating with phosphorus. The connections between
the supports are like rungs on the ladder and contain two types of paired bases. One pair is adenine and thymine
(A and T); the other is guanine and cytosine (G and C). A gene might be visualized as a certain length of the ladder
(which may be large or small) and may contain hundreds of bases which may be present in any order.
At the molecular level, the DNA bases are read three at a time to specify amino acids, which
are the building blocks of proteins. The sequence of the bases in the DNA somehow determines how other proteins
in the body are to be formed. Other proteins in the body serve either a structural function (such as bones and
cartilage) or as enzymes which are necessary for the chemical workings of cells. DNA thus controls the visible
expression of a gene (otherwise known as the "phenotype") by providing instructions for making protein
inthe body-somewhat like a cookbook for the different proteins in the body. Different phenotypes therefore, can
reflect different genetic instructions for building proteins-that is, different phenotypes can reflect genetic
of Section v
Genes, DNA, and Reductionism
Genes are molecular entities which can be inherited, and they specify how proteins
are built in the body. The molecules which contain genes are called DNA (deoxyribose nucleic acid). DNA is a long
molecule, which under a microscope takes the shape of a twisting ladder (often called a "double helix").
A portion of a strand of DNA can function as a gene - meaning that this portion carries the relevant code for production
of a particular protein.
Of course, proteins are important for every cell in the body. But to think that genes provide all of the instructions
for life by providing instructions for how proteins are built is to ignore many other factors that influence an
individual - even an individual's body. Genes, and difference in genes, may explain some of the differences between
people, but other factors also contribute to differences between people. Many other factors, including environment,
nutrition, and the family and culture in which a person is raised and lives can be at least as important to what
makes up a person as the way their proteins are constructed, but genetic studies tend to make people believe there
is a genetic "cause" for everything - this tendency is sometimes called "genetic reductionism."
a range of genetic engineering techniques has been developed to manipulate the genes or the genetic makeup of living
beings to produce a desired commercial result. These technologies are being used in many areas of production, such
as pharmaceuticals, industrial raw materials, and food. (For an example of how a plant may be genetically engineered,
see the highlight "How a Transgenic Plant is Made" below). Proponents of genetic engineering claim that
it is precise and safe, yet there is a great deal of controversy around these claims.
the term "genetic engineering" sounds like an exact science, in reality it is far from being precise
in any predictable manner. Critics of the technology, many of them scientists themselves, emphasize the unpredictability
of genetic manipulation as a primary reason for caution. Critics say that the discipline lacks adequate knowledge
of the many dynamic processes that contribute to the development and diversity of different plants and animal species
in our world. They observe that the science is being developed and commercialized with too little concern for the
risks of not knowing all of the consequences. Among the primary areas of concern, these scientists warn that:
Transgenic techniques are imprecise. Currently,
genetic engineers are not able to fully control where the foreign DNA is inserted into the host organism. This
control is important because it is believed that the position of genes can determine what they do. Genetic engineers
are not being mindful of the environment of the gene, and the dynamic role that all the other processes and forces
in a living being have in shaping the activities of genes.
Genes can perform more than one function,
depending on their environment and the influence of other factors. These multiple functions are not understood,
but they are also being ignored. So scientists focusing on the 'growth genes' to make salmon grow bigger were surprised
to find that the young fish also turned pale green. U.S. Department of Agriculture animal genetic engineers using
foreign growth hormones to make pigs grow bigger produced pigs with severe arthritis, lethargy, and other disorders.
Some of these multiple effects caused by foreign genes may not be so obvious at first, but instead may reveal themselves
over time in as yet unimagined ways.
Projects for the development of genetically
engineered plants and animals typically do not try to understand the way that the transgenic organism will interact
with other species once released into the world.
How a transgenic plant is made
Once genetic engineers have identified the genes that they want to introduce to the
agricultural crop, they construct a kind of package that will be introduced to the host agricultural plant. This
package is made up of:
the desired DNA
(genetic material), extracted from the isolated cell of the living being. (This is 'isolated' using enzymes, proteins
that function like scissors.)
a promoter, a stretch of DNA that acts
as a switch, ensuring that the foreign DNA is recognized and 'expressed' (employed to make the desired protein)
by the host organism.
a marker gene, so that genetic engineers
can tell if the foreign DNA has been successfully introduced into the host's cells. This gene most commonly is
resistant to antibiotics.
To actually introduce this package into the targeted agricultural plant, two methods
are commonly used:
1. A vector is used to force the gene into
the desired organism. Vectors are most commonly viruses, or bits of short sequences of bacterial DNA called plasmids,
because they function by breaking down the defenses in the host cells, and slipping into the cell's DNA.
2. A gene gun is used. The gene package is placed on large numbers of tiny gold (or
tungsten) bullets and fired into a plate of target plant cells
To make sure that the foreign gene has been taken up by the target organism, the cells
are flushed with antibiotics. The cells
that are carrying the 'package' with the antibiotic resistance marker genes will survive. Those cells that do not
have the package will not have resistance to the antibiotics, and will die. The surviving (transgenic) cells that
are left will be cultured, and grown into mature plants.
of Section v
Current Status of Human Genetic Research
Genetic studies are currently trying to identify and map out the long strings of molecules which
make up the entire genetic code, or "genome", of humans. Currently the federally-funded Human Genome
Project (HGP) is attempting to sequence all the estimated 3 billion bases in humans to arrive at a prototype or
"generic" sequence using mainly Northern European families. Of course, since every person's genetic makeup
is different, what is really being mapped out is supposed to be an "average" genome.
Although the HGP is one major project sequencing genes, there are a host of researchers doing
human genetic research. These projects may or may not be affiliated with the HGP. These research projects are conducted
by corporations, universities, and governmental agencies, and they are sometimes conducted in cooperation with
public health entities like the American Red Cross and others. Corporations are also trying to map out portions
of the "average" genome, and obtain patents over the parts they map out.
While some people are studying the "average" or "standard" genome, others
are studying variations within and between populations. An increasing number of projects now focus more directly
on human variation and diversity by sequencing the DNA of select, and supposedly more genetically "pure"
or "distinct," indigenous populations. Detecting genetic variation among indigenous populations becomes
easier if there is a "generic" sequence for comparison. As the HGP completes the "map" of the
"average" human genome, there will be increased interest in sampling indigenous populations in order
to study human diversity.
Variations in genes contribute to differences between people. It is believed that identifying
differences in genetic sequences between people may help determine what makes people different from one another,
or what makes groups of people different from other groups. Of course many other different factors also contribute
to differences, such as culture, language, environment, and lived experience. Genetics ignores these other factors.
Some people believe that if scientists can identify a variation, or difference, in genes that
equates to a significant difference in people (such as a different gene sequence that apparently causes immunity
to a disease), the discovery may have value-human and economic. This perceived value in the variation creates an
incentive to study people whom it is believed have a large amount of variation in their genetic makeup. The result
is a new "gold rush" where universities, governments, corporations, and private researchers are all seeking
to identify human genetic variation.
The actual focus of genetic studies varies widely. Some geneticists study traits we inherit
from our parents, some study similar traits within a population and differences between populations, some are looking
at genetics from a historical perspective to study the history of populations and their relationships with others,
while others are looking at current health-related questions. Among scientists interested in genetic engineering,
some are seeking to make changes in the genes of unborn fetuses, others are attempting to cause genetic changes
in an individual, others are attempting changes to the reproductive cells (which affects future generations of
the human species), and still others are experimenting with cloning techniques.
of Section v
Current Status of Agricultural Genetics
Every living species
has suddenly become a reservoir of potentially useful genes, or the possible host for the cultivation of interesting
genes or substances that can be later extracted.
Traditionally, farmers have diversified plant and animal breeds with selective breeding by crossing
different varieties from the same species to achieve desired characteristics such as taller plants or sweeter fruits.
Nowadays, however, the genetic engineering industry is using approaches that depart radically from traditional
agricultural breeding practices.
In agriculture, the most common genetic engineering techniques are transgenics and cloning.
Transgenics involves the deliberate breaking down of nature's borders, by crossing species that would normally
not interbreed. Transgenics works on the assumption that certain genes associated with the performance of certain
tasks, can be successfully transferred into other life forms, where they will continue to perform the same function.
Genetic engineers identify genes that they believe perform a particular function and then introduce them into the
agricultural plant or animal in the hope that these genes will continue to work in the same way in this totally
new environment. Examples of transgenic crop and animal experiments that have been attempted include introducing
fish genes into tomatoes, petunia flower genes into soybeans, bacteria genes into corn, cow growth hormones into
chickens, and human genes into tobacco, kiwifruit, mice, and sheep. Cloning techniques, based on the experiments
that produced the cloned sheep Dolly - will be used increasingly to mass produce livestock. It is estimated that
within 15 years, 85% of livestock in Great Britain will be cloned.
"A cow is nothing
but cells on hooves"
Thomas Wagner, animal
Fortune Magazine October 1987
Genetic engineering is being increasingly promoted in agriculture because of the backing of
large seed, agrochemical, and livestock companies that are investing billions into the new technologies. Food processing
companies are also encouraging this development, because they see that the new technologies can be used to create
raw materials better suited to their manufacturing processes.
Largely, genetic engineering is being developed to be able to maintain industrial agricultural
practices such as the use of intensive agrochemical and large-scale monocultural (one crop) plantations. So plants
and animals are engineered to cope better with the chemical and biological stresses that intensive farming places
on them and their environment. According to the companies, the most common aims of genetic engineering techniques
- to make plants resistant to agrochemical inputs such
- to make plants resistant to pests
- to make plants that can withstand drought conditions
- to make plants and animals "resistant" to diseases and viruses
This genetic research has to be constantly updated because weeds, pests, bacteria and viruses
will continue to develop resistance to the conditions designed to control them.
In addition, genetic engineering in agriculture is being used to push plants and animals beyond
their natural limits by
- increasing the productivity of each individual animal
(more meat, more milk, more wool, for example)
- creating plants that produce raw materials better suited to the processing industry (e.g., trees better suited
to the needs of paper and pulp companies)
- creating plants and animals that produce pharmaceuticals or "human" substances
In the last decade, genetic engineering in agriculture has boomed. The fascination of the Western
scientific community with the technologies and the promises by the genetic engineering companies of better agriculture
have encouraged billions in investment and an extremely cooperative attitude by governments worldwide. Hundreds
of thousands of genetically engineered organisms have been released into the environment for field trials. Every
living species has suddenly become a reservoir of potentially useful genes, or the possible host for the cultivation
of interesting genes or substances that can be later extracted.
Meanwhile, commercial cultivation is growing rapidly, due largely to the global reach of the
large multinational companies, which have been able to introduce their products almost simultaneously around the
world. In 1999, 100 million acres of genetically engineered crops were cultivated commercially worldwide - a 44%
increase from 1998. Over 50% of the US soybean crop and 62% of the Canadian canola harvest in 1999 were genetically
of Section v
Implications of Genetic Research for Indigenous Peoples
Research Ethics Fail to Address Concerns of Indigenous Peoples ó Conflict
with Common Indigenous Principles and Ethics ó Supplanting World Views ó Group View of Inheritance
and Ownership of Life
Gene Banking and Immortalized DNA ó Sanctity of Our Ancestors ó Euro-centric Scientific Theory and Discrimination ó Genetic Discrimination
and Genocidal Practices
ó Funding Priorities and ìTechno-Fixesî
research in general raises a complex range of legal, ethical, social, spiritual, and political issues which concern
indigenous peoples, and society at large. Indigenous peoples, and our territories, are at the forefront of genetic
research worldwide. We are immersed in genetic diversity-both in human and environmental (biodiversity) terms.
Lands that remain in the control of people indigenous to the area contain the majority of the biodiversity that
remains in the world. Our traditional knowledge about our surroundings, as well as many of the members of our own
ecosystems, is seen as the "new gold" in a rush to gain commercial benefit from nature. Since indigenous
populations represent a significant percentage of the world's human diversity, we are the subjects of scientific
curiosity. Indigenous knowledge systems and biological resources are therefore extremely threatened by appropriation.
people and nations must prepare themselves to critically evaluate proposals for research involving their people
and their territories. Policies which recognize and protect the collective rights of indigenous peoples are lacking.
We must accept the responsibility to put into place policies that protect our interests, and we must come to understand
the issues so that we can make fully informed decisions.
following sections will highlight some of the areas of potential concern regarding genetic research and indigenous
of Section v
Research Ethics Fail to Address Concerns of Indigenous Peoples
Initially, indigenous peoples were primarily concerned with the Human Genome Diversity Project (HGDP), a worldwide research
project initiated in 1992. Today, human genetic diversity research seems to be an aspect of every major genetic
research agenda, including the Human Genome Project.
Indigenous peoples are the subjects of evolutionary genetic research, genetic research to study differences in
how populations react to various pharmaceutical products (pharmacogenetics), and in single
nucleotide polymorphism (SNPs) research,
to name a few.
these efforts, indigenous peoples are largely unaware of the scale and potential impacts of human genetic research
on their communities. The typical human genetic research paradigm treats indigenous peoples as objects of curiosity,
rather than partners in research. The research is designed, funded, andimplemented without true and meaningful
consultation of the studied group.
has become evident that this new area of science and technology poses new challenges with regard to existing ethical
practices. Current bioethical protocols fail to address the unique conditions raised by population-based research,
in particular with respect to processes for group decision-making and cultural world views. Genetic variation research
is population-based research, but most ethical guidelines do not address group rights. In this context, one of
the challenges of ethical research is to include respect for collective review and decision making, while also
upholding the traditional model of individual rights. Indigenous communities are further disadvantaged in this
paradigm by being dependent solely on the researcher for information explaining the benefits and risks of the research.
standards in research involving human subjects require that the benefits of the research at least equal the risk.
Most population-based genetic research cannot meet this requirement because indigenous peoples are not the intended
beneficiaries of the research. As a result, researchers often offer other benefits unrelated to the genetic research
such as some short-term medical attention, technology transfer, training opportunities for students, or promises
of royalties for any commercial products developed.
Bad science is scientific research that harms people against their
It imposes itself on the subjects; it operates against the notion
It may be based on coerced consent, failing to reveal relevant information
to secure consent.
Research where the subjects do not stand to benefit.
Tribes can and must take control of any research activity that takes place within their territories and affects
of research designed to protect and benefit the subjects could be formalized in research agreements. But indigenous
peoples must be able to monitor and enforce these agreements. But how does one monitor the world-wide exchange
of genetic materials and data? What happens when agreements are violated? Who is responsible for the costs associated
with enforcement and monitoring agreements? Is money compensation (the only available remedy) the appropriate form
of restitution and remediation for broken agreements? These are questions indigenous peoples must take into consideration
before entering into research agreements.
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with Common Indigenous Principles and Ethics
Many indigenous peoples regard their bodies, hair, and blood as sacred
elements, and consider scientific research on these materials a violation of their cultural and ethical mandates.
Immortalization, cloning, or the introduction of genetic materials taken from a human being into another living
being is also counter to many indigenous peoples cultural and ethical principles.
Indigenous peoples have frequently expressed criticism of Western science for failing to consider the inter-relatedness
of holistic life systems, and for seeking to manipulate life forms using genetic technologies. Many indigenous
people have grave concerns about the short and long-term impacts of introducing genetically-modified life forms
into the environment.
of Section v
By focusing on reactions to changes in genetic materials in organisms
(including humans), genetics takes a very mechanistic view of the world. Life forms are viewed as mere machines,
in that the research tries to change one part of the "subject" organism in order to get different "output"
in terms of, for example, disease resistance or food production. The view is that, with enough experimentation,
eventually we will be able to design better "machines." This view is in conflict with a view that recognizes
the interrelatedness and interdependence of all living things. Tampering with one aspect of creation necessarily
has effects on all other aspects. Tampering with genetic materials in any life form, which developed over generations
in response to years of environmental influence, creates a risk of throwing everything else out of balance as well.
That life form had a place where it was specifically adapted to fit in. Tampering with the life form means changing
the balance and interrelationships that influenced the development of the organism, which could have broad "ripple"
of Section v
View of Genetic Inheritance
Two basic tenets of Euro-american society are that all property should
be alienable (for sale) and that all property should be owned by individuals. Current mainstream ethical protocols
generally assume that individual consent is all that is necessary for a person to share something of theirs - such
as genetic materials or knowledge about something. This is because the protocols, rooted in Euro-american thought,
assume that the individual has the right to sell or give away anything that is their own. This thinking is in conflict
with indigenous notions of group rights. For example, in many indigenous societies, people may not be free to sell
their knowledge because either the knowledge cannot be sold according to the group's ethical principles, or because
permission of a larger group is required first. Also, there may be responsibilities that go hand-in-hand with the
holding of traditional knowledge, and that is not usually part of what the Western "purchaser" or researcher
is concerned with at all-they just want the knowledge of how something works. Another example is that, if a person's
genetic material is sought because they are a member of some indigenous nation, most indigenous people would think
that the group ought to have a say in whether the individual's sample may be used as a representative of the nation.
After all, it is because the individual is part of the nation that the individual's genetic material is sought
at all, and all the members of the nation will be subject to the repercussions of any conclusions drawn from the
research. Therefore, indigenous peoples have a notion of group "ownership" of some things that is in
direct conflict with the Euro-american principles, and this means that in areas where we believe we have group
rights, these rights are ignored by the mainstream ethical protocols.
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and Ownership of Life
Much of the current research in genetics is being driven by a strange
twist in patent law. Patent laws grant a limited "intellectual property right" to someone who holds a
patent. The property right usually lasts from 17 to 20 years. Patents are usually granted for new inventions, as
a means of recognizing the inventor's innovation. Currently, the United States Patent Office is granting patents
to people who claim to uncover genetic sequences. This means that once a valuable gene is located and isolated,
it can be patented, and even mass-produced for commercial purposes.
the current law, patents are being granted for portions of all types of genes-human, animal, and plant. But many
people are opposed to the idea of patenting genetic sequences, because genetic sequences are part of a life form-which
nobody can claim to have invented. Patents were never intended to be granted for the "discovery" of life
forms. They were intended to provide some benefit to inventors of things-like mousetraps or toasters. Under the
current law, however, even your own genes can be patented, without you even knowing about it.
times indigenous peoples are not informed that their DNA can be commercialized through patents and used in the
development of new products. The potential commercialization of unique human DNA seems to be a significant motivation
behind many research projects. Three cases best exemplify the concern for patenting human genes. The U.S. Secretary of Commerce filed a patent claim on the
cell line of 26-year Guaymi woman from Panama
in 1993. A wave of international protest and action by the Guaymi General Congress led to the withdrawal of the
patent claim in late 1993. The Department of Commerce also filed patent claims on the cell lines of an indigenous
person from the Solomon Islands. This patent claim was also later abandoned. The U.S.
Patent and Trademarks Office (PTO) actually approved patents on the cells
lines of a Hagahai man from Papua New Guinea. The patents were granted to the U.S. Department of Health and Human
Services and the National Institutes of Health (NIH)
in March, 1994. Again the patent holders faced public outcry, and in late 1996 the NIH abandoned the patent. However,
the Hagahai cell line is now available to the public at the American Type Culture
Collection as ATCC Number: CRL-10528 Organism: Homo Sapiens (human) for $216
the present time, the US Patents and Trademark Office maintains a policy of granting patents for human genes, and
the genetic materials of other life forms. The USPTO is the prevailing model for the protection of intellectual
and property rights, worldwide, and is current adocated in international trade agreements such as the World Trade Organization. Patents on life forms are likely
to be a problem for the foreseeable future, unless and until citizens groups and other public advocates are successful
in securing legislation that prohibits patents on life.
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and Immortalized DNA
Genetic samples are frequently "immortalized" for future
study utilizing a technique of cell transformation which keeps cells viable for several years. Through immortalization,
a single sample is all scientists need to generate unlimited amounts of DNA for future research.
immortalized cell lines can be stored in various gene banks around the world. Control and monitoring of samples
is a critical issue, and it is very difficult to prevent abuses such as samples being used beyond the original
intent. It is almost impossible to tell who is using them and for what purpose.
DNA can be extracted from tissues and blood. Once the DNA is extracted, it is frozen and is stored for years. Again,
these samples can be transported to several different labs without the consent of the donor and used for studies
beyond their original intent.
of Section v Contents
of Our Ancestors
Collections of biological materials are taken not just from the living,
but also from the deceased. For most indigenous peoples this represents a serious violation of the sanctity of
our deceased ancestors. In a recent highly-publicized example, the Department of the Interior has approved a plan
for taking 10-20 samples from the remains of the Ancient One found at Kennewick, Washington, in order to determine
which part of the remains will be the best place to obtain further samples for DNA analysis. These studies are
being conducted despite protests from area indigenous peoples.
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Scientific Theory and Discrimination
a sense of urgency, the Human Genome Diversity Project (HGDP) proposes to collect the DNA samples of indigenous
peoples and store the collections in gene banks in order to "avoid the irreversible loss of precious genetic
information." Referring to indigenous populations as "isolates of historic interest (IHI's)" the
HGDP plans to immortalize the DNA of disappearing populations for future study. The initial conceptualization of
the HGDP has been widely criticized for its consideration of indigenous peoples as mere research subjects, with
little regard for the continued livelihood of the targeted populations. The HGDP has also been sharply criticized
for failing to consult with indigenous peoples throughout its planning processes.
expect to reconstruct the history of the world's populations by studying genetic variation to determine patterns
of human migration. In North America, this research is focused on validation of the Bering Strait theory. It is
possible these new "scientific findings" concerning our origins can be used to challenge aboriginal rights
to territory, resources, and self-determination. Indeed, many governments have sanctioned the use of genomic archetypes
to help resolve land conflicts and ancestral ownership claims among Tibetans and Chinese, Azeris and Armenians,
and Serbs and Croats, as well as those in Poland, Russia, and the Ukraine who claim German citizenship on the grounds
that they are ethnic Germans. The secular law in many nations including the United States has long recognized genetic
archetypal matching as a legitimate technique for establishing individual identity.
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ability to screen a person's genetic material could lead to genetic discrimination. Corporations, for example,
may someday demand genetic testing and refuse to hire individuals who carry certain genes. Insurance companies
may raise the premiums, or refuse to cover, individuals who have been "genetically identified" as having
a predisposition for some disease. Already some genetic studies have sought to reinforce social stereotypes and
stigmatization in ways such as searching for "the binge drinking gene." Whether the intentions behind
the design of such research projects are innocent or not, it remains clear that indigenous peoples must face the
real possibility of discrimination and stigmatization in this area as in many other areas of life.
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and Genocidal Practices
is an attempt to "improve" the genetic composition of individuals or entire peoples. Genocide is an attempt
to eliminate whole peoples from existence. Many people are concerned that genetics may entail forced sterilization
or abortion of those found to possess "undesirable" genetic sequences. Some geneticists already talk
of attempting genetic manipulation on fetuses, in order to "fix" potential genetic problems found them.
learning about the basics of genetics, some people fear the specter of genetically specific warfare-weapons designed
only to impact individuals with certain genetic traits. Until now, biological warfare has been "sloppy"-along
the lines of just introducing a virus in an area where it infects a lot of people. Genetically-based biowarfare
would target individuals within a population with specific genetic traits, and not affect other people directly.
There are three basic requirements for genetic biowarfare to be possible:
(1) a good understanding of the basic, average
human genome (the same goal as that of the HGP);
(2) identification of how different populations
differ in their genetic material (the same goal of SNPs (single nucleotide polymorphism) research and human genetic
diversity research currently being conducted); and
(3) research discovering how to take advantage
of the differences among populations in order to "target" weapons based on genetic differences. While
we are not there yet, all of the human genetic research currently being conducted takes us closer to the possibility
of genetically-based biowarfare.
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Priorities and "Techno-Fixes"
millions of dollars in the federal budget are being spent to support genetic research. You might question whether
this is an appropriate use of federal funds. For example, many public health advocates would like to see federal
money currently spent to discover genes associated with diabetes redirected to more practical solutions, like education
and other strategies to encourage exercise and dietary changes, as well as providing nourishing foods to people
who can't afford to buy food at market prices.
questions should be directed at policies whereby vast resources are spent in the search for genetic causes of diseases,
and these expenditures are followed by more expenditures, this time for research into how to "fix" people
who have "flawed" genetic material (assuming this can even be done!). Public health advocates make a
good argument that even to view the problem as a "flaw" in genetic makeup is wrong, and to view the solution
as a technological one is wasteful. In many cases, preventative measures would help people deal with their problems
in a quicker, more effective, and less costly way. But those interested in conducting genetic research-researchers
and bioscience corporations-are not likely to point out that there are more effective uses of public money than
finding "techno-fixes." It is up to us to say so if we don't want our tax money spent to support genetic
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Problems with Genetics in Agriculture
and Owning Life
New Species ó Farmers and Farming Communities
ó Health ó Technical Solutions Cannot Fix Policy Problems
and Owning Life
Intensive agriculture, mineral exploitation, and industrial production
have led to massive and rapid genetic erosion and loss of agricultural biodiversity. The United Nations Food and
Agriculture Organization estimates that 75% of agricultural species have been lost over the last hundred years,
largely as a result of industrial farming practices. Genetic engineering is being developed and mass-marketed by
transnational agribusiness. Where the trend is to develop broad international markets for a single product, genetic
uniformity through large, monocultural (single crop) rural landscapes is likely to continue.
these trends threaten indigenous peoples and small-scale farmers is that genetic engineering companies are now
increasingly interested in reaching out to the small farmers and rural peasant communities, in the hope of replacing
diverse agricultural crops with their genetically engineered seeds. The seed companies are moving into centers
of diversity and origin: Monsanto potatoes are being introduced into the Andes, origin of the potato. Genetically
engineered corn is being introduced to Mexico, where thousands of years ago, the Mayan people domesticated and
indigenous peoples are concerned about the theft of plant and animal species by the genetic engineering companies.
Since 90% of the diversity of life forms is in developing countries, largely under the protection of indigenous
and peasant rural communities, plant genetics companies have been prospecting in these territories. They are interested
in the plant and animal species, and in the indigenous knowledge of the properties of these species for food and
medicinal purposes. In many cases, the companies are taking species without the knowledge or consent of the local
indigenous people, and then illegitimately claiming legally-enforceable ownership over these plants and animals.
They are applying for and receiving patents on plants and animals. The patents define the company as the inventor
and exclusive owner of the living being. As a result of patenting life forms, all genetically engineered seed that
is being tested and planted in the fields, and all genetically engineered foods in shops, restaurants, and supermarkets
is under the patent control of the genetic engineering companies.
addition to the idea of owning life, many people object to patenting plants because the patents give seed companies
monopolies over plants. Farming organizations in particular are concerned about this development, in light of the
rapid consolidation of the seed and agrochemical industries that has taken place in the last few years.
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The introduction of any new species will impact the existing life in
that territory. The new species may compete with indigenous or other species for water, food, or sunlight, or it
may change the nature of the food chain (such as the nutrients in the soils), threatening the survival of species
that depend upon the relative stability in the ecosystem. In the last decade, a number of ecological risks have
been discovered after genetically engineered organisms were released into the environment. These risks have become
the subject of intense debate among the seed companies, academic and corporate scientists, and concerned public
main concern is that genetically engineered plants are exchanging their genetic material with other species, and
creating new species and new ecological problems affecting the web of life well beyond the human food web. In many
cases, the risks are not being discovered until after the release and mass commercialization of genetically engineered
organisms. The risks are therefore not potential but actual, because genetically engineered organisms have already
been introduced into thousands of places around the world.
genetic contamination is a particular threat to indigenous peoples and their territories, which have become havens
of biodiversity in the world.
How genetically modified organisms
can become 'pollution'
Carried by the wind, by riverways or animal-born, the
pollen or seeds of genetically modified plants and trees is transported across distances, cross fertilizing, cross-pollinating
or germinating as life forms tend to do.
Streams, rivers, lakes and oceans are
at risk as genetically engineered fish
may escape from their captive breeding places and into the wilds. It is currently estimated that even a few genetically
engineered fish could replace an entire population of wild fish, due to natural spreading of their introduced traits.
Genetically modified crops that have been
approved by the federal agencies enter into a wide range of processed foods. Living food entities like potatoes
can reseed, if composted before use, while foods such as tomatoes, corn kernels and cereal grains that are still
viable seeds can pass intact through digestive systems and then out again into the earth.
New bacteria and viruses that result from
the processes of genetic engineering, and from the new life forms that they create may enter into diverse ecosystems
with the force of epidemics.
Animal feed that is bought to supplement
diets of domestic livestock could contain genetically engineered ingredients.
Wild honeybees, butterflies and other insects
may take pollen from genetically engineered crops, those that are directly cultivated or those that have escaped
from the fields.
Wild animals that are hunted for food
may have consumed genetically engineered crops from cultivated fields. Birds, for example, may have eaten seed
from cultivated genetically engineered crops or escaped genetically modified plants.
Birds of prey that eat small wild animals
that have fed on genetically modified crops will also be vulnerable to the unknown effects.
Genetically engineered crops cultivated in or near regions where there are
domesticated and wild related varieties (i.e., that are centers of origin
or centers of diversity for that crop) are likely to exchange their genetic material, including the genetically
engineered traits, and thus become part of the wider environment.
Superweeds and Superpests
Related varieties of plants commonly interbreed naturally. This is
called "outcrossing". There is evidence that points to the transfer of herbicide and pest-resistance
from genetically engineered varieties to agricultural or wild relatives. This is most likely to happen in centers
of origin or diversity of plants, where there are a wide variety of relatives in farming and the wild. Mexico,
for example, is the center of diversity and origin of corn, while the Andes are the center of origin and diversity
of potatoes. When the genetically engineered traits are passed on to wild relatives, new varieties are created
that may have a fitness advantage over the indigenous plants and threaten their survival. In the case of herbicide
resistance and pest-resistance, there are two broad areas of concern: superweeds and superbugs.
and weedy relatives that receive the capacity for herbicide resistance may create superweeds that survive herbicides
farmers usually apply, forcing them to buy additional and possibly more intensive weed-killers that are more harmful
to farmers, their families and the environment.
populations are known to develop resistance to pesticides. This process is accelerated with plants genetically
engineered to produce pest-toxins on a constant basis, since pests are under increased pressure to develop resistance
for their own survival. The U.S. Environmental Protection Agency estimates that insects could develop full resistance
to the widely cultivated Bt-crops (crops engineered to produce a pesticide) within 3-5 years.
addition, crops engineered to produce toxins to kill insects that usually harm the harvest of that plant are also
killing non-target insects that do not harm the harvest, but help farmers. The Scottish Crop Institute found that
pest-resistant potatoes were not only killing the targeted aphids (potato pests), but insects further up the food
chain. Ladybugs - insects that help farmers by feeding on aphids - were affected when they ate aphids that had
eaten the pest-resistant potatoes. The ladybugs' life span was halved and they laid fewer eggs than ladybugs that
fed on a normal diet. Meanwhile, Cornell University researchers found that Monarch butterfly caterpillars suffered
high mortality rates when pollen from the insect-resistant corn blew onto milkweed - the food of the Monarch and
a common border neighbor of corn.
engineered and in field trials today
Alfalfa, Apple, Asparagus, Barley, Beet, Belladonna,
Bermudagrass, Carrot, Chicory, Chrysanthemum, Coffee, Corn, Cotton, Cranberry, Creeping bentgrass, Cucumber, Eggplant,
Grape, Grapefruit, Kentucky bluegrass, Lettuce, Melon, Oat, Onion, Papaya, Pea, Pear, Peanut, Pelargonium, Pepper,
Petunia, Persimmon, Perennial rye grass, Pine, Pineapple, Plum, Poplar, Potato, Rapeseed, Rice, Soybean, Spruce,
Squash, Strawberry, Sugarcane, Sunflower, Sweetgum, Sweet Potato, Tobacco, Tomato, Walnut, Wheat
of Section v
Bad for Farmers
and Farming Communities
Genetic engineering is jeopardizing farmer's livelihoods in a number
insurance companies are not insuring farmers for loss of markets and market premiums due to contamination of their
conventional or organically grown produce by neighboring genetically engineered crops.
the same time, the seed companies are actively fighting legislation that will make them liable for environmental
or health damages resulting from their products. In this vacuum of responsibility, farmers are among the first
are being prosecuted for theft and illegal use of patented seed when they may have been innocent victims of outcrossing
of genetically engineered crops onto their farm.
markets are lost through the market advantages that patents on plants provide to seed companies. For example, basmati
rice, a highly prized rice variety developed and cultivated for centuries by Indian and Pakistani farmers, was
pirated and patented by Ricetec, a Texas-based company. Under Ricetec's patent rights, Indian and Pakistani farmers
can no longer export their basmati rice to the U.S., where the Ricetec patent applies.
"Terminator" and "Traitor" Seeds
farmers who rely upon seed-saving and informal seed exchange number about 1.4 billion across the world. Interested
in their business but concerned by their seed-saving practices, several companies have developed seed sterilization
techniques that put chemical or biological locks on seeds. These techniques destroy the ability of the plants to
produce their own viable seeds. In this way, the seed companies seek to ensure that farmers have to return to the
seed market each planting season. It is feared that outcrossing, through processes such as cross-pollination, could
spread genetically engineered seed sterility into other species. Appropriately labeled "Terminator" technologies,
they have been widely opposed and are the subject of bans in India, and in states such as Maryland. In spite of
sustained condemnation, the U.S. Department of Agriculture and Delta and Pine Land Co. continue to develop them.
but younger, plant technology is "Traitor" technology. This technology involves using an external chemical
to "turn on or off" genetic traits in plants. As an example, companies may try to "turn off"
a plant's natural defense mechanisms, and thus make use of pesticides necessary to successfully grow the plant.
The most obvious implication of this technology is an increased dependence on chemicals for agriculture. Other
frightening implications also loom-like the possibility for applications in biowarfare. The Terminator and some
Traitor traits are carried in the pollen of the plants containing them, so the possibility of outcrossing into
nonintended species is a real danger.
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exposed to risks when genetically modified organisms are released and interact with the living world and the web
of life. Following are some ways in which human health is threatened by genetic engineering.
critical of the speed and lack of adequate regulation around genetic engineering are concerned about the possibility
of new viruses and diseases that could result from transgenics. In particular, the widespread use of viruses and
bacteria is a cause for concern, because of the ability of viral and bacterial strains to exchange and absorb new
for example, is a technology in which animals, such as pigs, are bred as organ-donors for human patients. Xenotransplantation
involves, for example, the introduction of human genes to the pig to reduce the likelihood of a pig organ being
rejected when transplanted into a human patient. There is great concern among critics of this technology that it
will expose humans to new viruses that, until now, have affected animals alone. This means that humans could be
exposed to pig viruses that may not only affect the human patient, but may be passed on to countless other humans.
So we need to compare the potentially huge risk to human populations with the supposed benefits: it is estimated
that if it worked perfectly, xenotransplantation would increase life expectancy across the human population by
only about 0.02%.
are also exposed to risks when we eat genetically modified organisms. We may be eating genetically engineered foods
directly either as whole foods, such as corn, potatoes, tomatoes, and soybeans, or as ingredients in processed
foods, such as vegetable oils and fats, corn or potato starch, and additives such as soy-based lecitin. Many of
these foods are incorporated into thousands of processed foods. Soy, for example, is said to be used in over 60-70% of processed foods.
for consumption in the U.S.
Canola, Chicory, Corn, Cotton, Flax, Papaya, Potato,
Soybean, Squash, Sugarbeet, Tomato
we eat animal products such as meat and dairy products, we may also be exposed to genetically modi fied organisms.
This is because a great deal of animal feed is made from crops now widely genetically engineered. It is estimated
that around 90-95 per cent of soybean harvests and 60 per cent of traded corn are genetically engineered.
of the main concerns with eating genetically engineered foods include:
New toxins resulting from the genetic engineering
process and the presence of foreign genes and viruses. Traces of some toxins are enough to cause severe harm, yet
are easily missed in tests, especially if they are only present at certain times (for example, weather conditions,
stress). Genetic engineering is more likely to produce new toxins than traditional plant breeding, because it introduces
genes that produce toxins that are new to the host plants. While acute toxicity is immediately noticeable, chronic
toxicity may only take effect over time, through constant exposure-symptoms may not show up for years. Most genetically
engineered foods currently on the market are staple foods eaten on a daily basis, so our exposure can be very high
Antibiotic resistance genes (used to indicate
whether the transfer of foreign genes has been successful) could integrate with beneficial bacteria in the human
digestive system. These in turn could combine with pathogenic (dangerous) bacteria, to develop new virulent strains
of harmful bacteria that are resistant to antibiotics. In this way, we would be faced with serious infections that
we can not treat with traditional antibiotics. For this reason, countries such as Norway have banned the import
or cultivation of all crops with antibiotic resistance genes.
Exposure to agrochemical and pesticidal toxins
is dramatically increased with the production of herbicide-resistant and pesticide producing food crops. Monsanto's
widely commercialized herbicide-resistant soybeans were safety-approved on the basis of tests that did not apply
herbicide to the soybeans. Yet there have been a number of studies linking exposure of farm workers to Monsanto's
RoundUp herbicide with illness and cancers. For example, one of the most rapidly increasing strains of cancer in
the Western world - non-Hodgkins lymphoma - is linked with exposure to the active ingredient of RoundUp - glyposhate,
as well as another common herbicide, MCPA.
case of the Bt pest-resistant crops, there are no clear, independent studies on the effects of eating foods with
the pesticide in them. The bacterium in isolation, not the Bt-bacterium produced in the plant, has been safety
tested, without confirmation that the two forms of Bt are the same.
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Solutions Cannot Fix Policy Problems
Genetic engineering in agriculture is receiving huge financial support
from governments around the world because of its attractive promise of solutions to agronomic, farming, and food
security problems. This represents an important decision-making issue for communities on how problems are to be
addressed, and who will provide the solutions.
there is a tendency among governments and the seed companies to present genetic engineering as a miraculous solution
for problems that cannot be solved by laboratory techniques. Seed cannot be genetically engineered to restore fairness
to markets that currently squeeze out small farmers with low commodity prices, nor can it be engineered to deal
with distribution inequities that contribute to famine and malnutrition. Does it make sense to create, and even
support, all the risks to health that genetic engineering creates, when there are other- proven and safer- methods
for addressing hunger?
the over-emphasis on genetic engineering is a problem because resources are being diverted into solutions that
set up distant company headquarters as the problem-solvers, rather than the communities or groups that should be
empowered to develop solutions for their own people. Rice is currently being genetically engineered to provide
higher levels of vitamin A where malnutrition and starvation is high. Critics argue that this approach is a high-risk,
techno-fix that is diverting millions of dollars towards a program that does not involve local communities in the
process. Moreover, the project has focused on only one of the nutrient deficiencies in communities where famine
exists-a lot more than vitamin A is lacking in starving peoples' diets. And it will take considerable money and
efforts to educate the local people to grow and eat the rice, which is yellow rather than white. People critical
of this scheme note that working with local communities to diversify farming to include the growing of leafy green
vegetables would better address the wider nutritional problems facing areas of famine.
of Section v
What Can Indigenous People Do?
research is a given. It will continue. The potential problems are also a given. We must address them. This does
not mean that we must just come to terms with the problems, and be prepared for the worst case scenario. Rather,
the challenge we face is to ensure that the research will be conducted under the utmost ethical standards and that
genetic information will be used wisely. There are many things that people, including indigenous people, can do
to this end. There are also many things that indigenous people specifically, because of our world view and because
of our unique political situations, can and must do.
and foremost, indigenous peoples must regulate
any activity that potentially may result in the extraction of genetic resources from their people or their territories. This places a burden on indigenous peoples, probably heaviest on tribal leadership, to be
informed about the issues and to be prepared to control and manage research activity within their jurisdictions.
Since there are no special laws (only ethical guidelines not backed by legal control) to regulate the activities
of scientific researchers in the field, tribes must exercise their own sovereign power to regulate these activities
in order to protect themselves and their people. This can be done by enacting local laws (ordinances, tribal codes)
which regulate every aspect of research within tribal jurisdictions to ensure that community interests are protected.
A model tribal ordinance is available on the IPCB website at www.ipcb.org.
aspect of successful tribal control of research is a commitment to train local community members who can take responsibility
for review, oversight, and recommendations concerning research proposals to the governing authority. Tribes should
not have to bear the financial burden of training and technical assistance alone, especially when the research
is initiated by outside interests.
leaders can also demand that federal spending
priorities be shifted away from genomic research in favor of funding programs and services that produce real outcomes
and benefits for the community. For instance, instead of allocating
federal funding for non-beneficial research such as the search for the "binge-drinking" gene, funding
should be spent on proven strategies, such as treatment programs. Instead of diverting precious resources to a
search for "the diabetes gene(s)," funding should be allocated to programs that provide direct benefits
in improving diets, exercise, and lifestyles.
leadership can advocate at the federal level
for improvements in policies regulating the framework in which funding decisions and research projects are carried
out. For instance, genetic researchers and their funders frequently
fail to consult with tribal governments, assuming instead that individual informed consent is all that is necessary
to carry out their research in an ethical manner. When the research impacts the entire community, which is always
the case if the research is "population" or "race-based" research, this is a real problem.
Tribal leaders can and should demand ethical protocols that respect tribal rights to consultation and sovereign
authority. Such protocols should be adopted, and enforced, by the federal agencies carrying out or providing the
funds for research on tribal communities or their territories.
Education of tribal community members should be a priority for Indigenous people concerned about biocolonialism, because until community
members are aware of the issues, they are vulnerable to abuses from unethical research practices. Community education
can be accomplished by organizing forums and workshops on the topics of genetic research or biocolonialism. Anyone who has read this book already knows enough to start
sharing their knowledge in a way that will help others. IPCB and
other interested organizations can make available resource persons and educational materials to support such forums.
Community radio programming is also an excellent outreach tool. The topic of biocolonialism should also become
a regular topic of discussion on the agendas of on-going regional conferences, because it impacts so many important
areas of Indigenous peoples lives, such as education, the environment, cultural resources, natural resources, and
general sovereignty concerns.
addition to regulating research, tribes can also develop and implement policies regulating or preventing the introduction of genetically altered organisms
within tribal jurisdictions, including Indian-owned land and leased land. To augment this approach, tribes can also offer
education about the issues of genetically engineered organisms to landowners and lessees in the area surrounding
the tribal jurisdiction, in order to help prevent migration of genetic "pollution" onto tribal land.
concerned about the idea of allowing patents
on life forms can take individual action by joining existing campaigns
(like the No Patents on Life campaign headed by the Council for Responsible Genetics) and by encouraging local
actions. Possible local actions include tribal declarations that tribal land and resources are patent-free zones,
where no patents on life forms will be allowed. Another potential local action is for tribes themselves to take
actions, on federal and international levels, declaring the entire tribe's opposition to the concept of patenting
concerned about genetically engineered foods can avoid highly processed and mass marketed foods, since these are more likely to contain
genetically modified ingredients. Buying such foods encourages the marketing, and increases the profits of the
corporations that promote genetically engineered foods. As an alternative, whenever possible people can buy locally
produced foods, encourage local farming and seed-saving and exchange to promote diversity of local crops, and even
promote revival of a more traditional diet.
hope that this publication has helped you. We will consider it a success if you feel more informed, and if it leads
to your making decisions based on information we have provided or that we have helped you find. We hope that we
have provided enough material to allow those who are interested to begin to address biocolonialism in their own
communities. We encourage you to talk about these issues. We will all be affected by how we as indigenous peoples
decide to deal with the issues. Talking about them is the first step towards protecting ourselves and our relations
from abuses, and towards ensuring that the wisdom of our ancestors is brought to bear on something that is sure
to impact our future.
of Section v
Exploding the Gene Myth. Hubbard, Ruth and
Wald, Elijah. Beacon Press, Boston, MA, 1999, 0-8070-0419-7
The Biotech Century. Harnessing the Gene and Remaking the World. Rifkin, Jeremy.
Jeremy P. Tarcher/Putnam, 1998, 0-87477-909-X
to Primer Index